Dimeric Architecture of the Human Bumetanide-Sensitive Na-K-Cl Co-transporter
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چکیده
منابع مشابه
Dimeric architecture of the human bumetanide-sensitive Na-K-Cl Co-transporter.
The primary mediator of NaCl reabsorption in the renal distal tubule is the human bumetanide-sensitive Na(+)-K(+)-2Cl(-) co-transporter (hNKCC2), located at the apical membrane of the thick ascending limb of Henle's loop. The physiologic importance of this transporter is emphasized by the tubular disorder Bartter syndrome type I, which arises from the functional impairment of hNKCC2 as a result...
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cells, are similarly present on some Tregs. As a result, Tregs home to the same regions in inflamed organs as their proinflammatory targets to control exuberant immune responses. This notion is suggested by several studies in the recent years13,14; however, Eller et al.1 did not find Tregs in inflamed kidneys of wild-type animals. This observation is surprising because it contradicts previous s...
متن کاملMutation of the Na-K-Cl co-transporter gene Slc12a2 results in deafness in mice.
Hearing impairment is a common human condition, but we know little about the molecular basis of cochlear function. Shaker-with-syndactylism (sy) is a classic deaf mouse mutant and we show here that a second allele, sy(ns), is associated with abnormal production of endolymph, the fluid bathing sensory hair cells. Using a positional candidate approach, we demonstrate that mutations in the gene en...
متن کاملAnterior segment physiology after bumetanide inhibition of Na-K-Cl cotransport.
PURPOSE To determine the effect of bumetanide inhibition of Na-K-Cl cotransport on aqueous humor formation and outflow facility in living cynomolgus monkeys, outflow facility in organ-cultured human eyes, and contraction in bovine ciliary muscle and trabecular meshwork strips, in vitro. METHODS Aqueous humor formation in monkeys was measured fluorophotometrically for 6 hours, 1 to 6 weeks bef...
متن کاملHomo- and hetero-dimeric architecture of the human liver Na⁺-dependent taurocholate co-transporting protein.
The NTCP (Na⁺-taurocholate co-transporting protein)/SLC10A [solute carrier family 10 (Nav/bile acid co-transporter family)] 1 is tightly controlled to ensure hepatic bile salt uptake while preventing toxic bile salt accumulation. Many transport proteins require oligomerization for their activity and regulation. This is not yet established for bile salt transporters. The present study was conduc...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2003
ISSN: 1046-6673,1533-3450
DOI: 10.1097/01.asn.0000097370.29737.5b